In recent years, we have witnessed groundbreaking strides in additive manufacturing, steering innovative solutions in tissue regeneration with a particular emphasis on burn wound treatment and bone tissue engineering. These advances revolve around the potential of hydrogel materials, a focal point in this paradigm shift, celebrated for their soothing and moisturizing attributes which have become indispensable in clinical settings.
As pioneers in this field, we leverage the potent synergy of gelatin, alginate, and bioactive borate glass (BBG) to craft 3D-printed dressings that stand poised to redefine burn wound care. These cutting-edge dressings not only showcase enhanced mechanical properties but also nurture an environment fostering cell viability, a development crucial in transforming the treatment landscape for second-degree burns through sustained hydration and encouraging tissue remodeling.
Parallelly, our team is deeply engaged in enhancing scaffold materials for bone tissue engineering, diving into the realms of 3D bioprinting and scaffold creation with a focus on the angiogenic potential of borate bioactive glasses. We intricately explore the compositions intertwining polymers like polycaprolactone (PCL) and polylactic acid (PLA) to forge scaffolds boasting complex pore geometries and structures.
Through meticulous research, we delve into the critical parameters influencing bone regeneration post-implantation, analyzing the impact of diverse factors on cellular behavior over time, including the potentials encapsulated in growth factors like bone morphogenetic protein-2 (BMP-2).
Join us as we stand at the threshold of a new era, we are dedicated to pushing the boundaries further, nurturing environments conducive to tissue repair and regeneration, thus inching closer to developing solutions that mimic the complexity and dynamism of in vivo conditions. Together with you, we aim to unlock the revolutionary potentials harbored in 3D bioprinting, paving the way for unprecedented solutions in burn wound healing and bone tissue engineering.
Recent Publications
2023
Fayyazbakhsh, Fateme, Michael J. Khayat, Candy Sadler, Delbert Day, Yue-Wern Huang, and Ming C. Leu. “3D-printed hydrogels dressings with bioactive borate glass for continuous hydration and treatment of second-degree burns.” International Journal of Bioprinting (2023): 0118.
2022
Fayyazbakhsh, Fateme, Michael J. Khayat, and Ming C. Leu. “3D-printed gelatin-alginate hydrogel dressings for burn wound healing: A comprehensive study.” International Journal of Bioprinting 8, no. 4 (2022).
Fayyazbakhsh, Fateme, Michelle Amato, Michael J. Khayat, Amanda Patton, Delbert E. Day, and Ming C. Leu. “In-vivo evaluation of 3D printed hydrogel wound dressings for burn wound healing.” In Tissue Engineering Part A, vol. 28, pp. S537-S538, Mary Ann Liebert ,2022.
2021
Fayyazbakhsh F., Khayat M., Amato M., Day D. E., Leu M. C. “In vivo Evaluation of 3D Printed Hydrogel Wound Dressings for Burn Wound Healing”, TERMIS SYIS Seminars – 6th World Congress of the Tissue Engineering and Regenerative Medicine International Society (TERMIS 2021) September 2021, Maastricht, Netherlands.
Fayyazbakhsh F., Amato M., Khayat M., Day D. E., Huang YW., Leu M. C. “3D Bioprinting of Cell-Laden Scaffolds for Skin Substitutes” , 49th North American Manufacturing Research Conference (NAMRC 49), June 2021.
2020
Fayyazbakhsh, Fateme, and Ming C. Leu. “A brief review on 3D bioprinted skin substitutes.” Procedia Manufacturing 48 (2020): 790-796.
Kolan, Krishna CR, Julie A. Semon, August T. Bindbeutel, Delbert E. Day, and Ming C. Leu. “Bioprinting with bioactive glass loaded polylactic acid composite and human adipose stem cells.” Bioprinting 18 (2020): e00075.
Kolan, Krishna CR, Yue-Wern Huang, Julie A. Semon, and Ming C. Leu. “3D-printed biomimetic bioactive glass scaffolds for bone regeneration in rat calvarial defects.” International journal of bioprinting 6, no. 2 (2020).
2019
Kolan, Krishna CR, Julie A. Semon, Bradley Bromet, Delbert E. Day, and Ming C. Leu. “Bioprinting with human stem cell-laden alginate-gelatin bioink and bioactive glass for tissue engineering.” International journal of bioprinting 5, no. 2.2 (2019).
Kolan, Krishna CR, Jie Li, Sonya Roberts, Julie A. Semon, Jonghyun Park, Delbert E. Day, and Ming C. Leu. “Near-field electrospinning of a polymer/bioactive glass composite to fabricate 3D biomimetic structures.” International Journal of Bioprinting 5, no. 1 (2019).
2017
Thomas, Albin, Krishna CR Kolan, Ming C. Leu, and Gregory E. Hilmas. “Freeform extrusion fabrication of titanium fiber reinforced 13–93 bioactive glass scaffolds.” Journal of the mechanical behavior of biomedical materials 69 (2017): 153-162.
Murphy, Caroline, Krishna Kolan, Wenbin Li, Julie Semon, Delbert Day, and Ming Leu. “3D bioprinting of stem cells and polymer/bioactive glass composite scaffolds for bone tissue engineering.” International Journal of Bioprinting 3, no. 1 (2017).
2016
Murphy, Caroline, Krishna CR Kolan, M. Long, Ming-Chuan Leu, Julie A. Semon, and D. E. Day. “3D printing of a polymer bioactive glass composite for bone repair.” International Solid Freeform Fabrication Symposium (2016): 1718.
2015
Thomas, Albin, Krishna CR Kolan, Ming C. Leu, and Gregory E. Hilmas. “Freeform extrusion fabrication of titanium fiber reinforced bioactive glass scaffolds.” International Solid Freeform Fabrication Symposium. 2015.
Kolan, Krishna CR, Albin Thomas, Ming C. Leu, and Greg Hilmas. “In vitro assessment of laser sintered bioactive glass scaffolds with different pore geometries.” Rapid Prototyping Journal 21, no. 2 (2015): 152-158.
2014
Liu, Wai-Ching, Irina S. Robu, Rikin Patel, Ming C. Leu, Mariano Velez, and Tien-Min Gabriel Chu. “The effects of 3D bioactive glass scaffolds and BMP-2 on bone formation in rat femoral critical size defects and adjacent bones.” Biomedical Materials 9, no. 4 (2014): 045013.
2013
Kolan, Krishna CR, Ming C. Leu, Gregory E. Hilmas, and Taylor Comte. “Effect of architecture and porosity on mechanical properties of borate glass scaffolds made by selective laser sintering.” International Solid Freeform Fabrication Symposium. 2013.
2012
Kolan, Krishna CR, Ming C. Leu, Gregory E. Hilmas, and Mariano Velez. “Effect of material, process parameters, and simulated body fluids on mechanical properties of 13-93 bioactive glass porous constructs made by selective laser sintering.” Journal of the mechanical behavior of biomedical materials 13 (2012): 14-24.
2012
Velez, Mariano Garcia, Steve Jung, Krishna CR Kolan, Ming-Chuan Leu, D. E. Day, and Tienmin Chu. “In vivo evaluation of 13-93 bioactive glass scaffolds made by selective laser sintering (SLS).” Ceramic Transactions, vol. 237, pp. 91 – 99, American Ceramic Society (ACS), Oct 2012.
2011
Doiphode, Nikhil D., Tieshu Huang, Ming C. Leu, Mohamed N. Rahaman, and Delbert E. Day. “Freeze extrusion fabrication of 13–93 bioactive glass scaffolds for bone repair.” Journal of Materials Science: Materials in Medicine 22 (2011): 515-523.
Huang, Tieshu, M. N. Rahaman, Nikhil D. Doiphode, Ming C. Leu, B. Sonny Bal, D. E. Day, and Xin Liu. “Freeze Extrusion Fabrication of 13-93 Bioactive Glass Scaffolds for Repair and Regeneration of Load-bearing Bones,” Biomaterials Science – Processing, Properties, and Applications, American Ceramic Society, Jan 2011.
Kolan, Krishna CR, Ming C. Leu, Gregory E. Hilmas, Roger F. Brown, and Mariano Velez. “Fabrication of 13-93 bioactive glass scaffolds for bone tissue engineering using indirect selective laser sintering.” Biofabrication 3, no. 2 (2011): 025004.
Huang, T. S., M. N. Rahaman, N. D. Doiphode, Ming C. Leu, B. S. Bal, D. E. Day, and X. Liu. “Porous and strong bioactive glass (13–93) scaffolds fabricated by freeze extrusion technique.” Materials Science and Engineering: C 31, no. 7 (2011): 1482-1489.